TRISTAN TECHNOLOGIES Tristan Technologies, Inc. EchofMCG™ SQUID system for fetal Cardiac Measurements

The EchofMCG ™ is a unique multi-channel vector fMCG system integrated with an echocardiography system, capable of simultaneously performing fetal magnetocardiography (fMCG) and echocardiography (echo/Doppler). Such linking of echo/Doppler and fMCG would allow the clinician to analyze the fetus rapidly for both hemodynamic as well as electrophysiologic abnormalities, such as fetal arrhythmias. This will be the world first clinical modality to provide full characterization of the intrauterine condition of fetuses with life threatening heart conditions.

SQUID = Superconducting Quantum Interference Device.

• Simultaneously detection of both ultrasound and magnetic fields associated with fetal cardiac electrical activity
• Vector gradiometer design to maximize captured fMCG information
• Small probe profile for easy positioning in close proximity to fetus
• Gantry movement offers four degrees of freedom for patient accommodation

Tristan’s Model 624–EchofMCG vector SQUID Dewar and Probe

System Configuration

• 7-element vector sensor array
• 1st order gradiometers with 8-cm baseline
• Gantry with (x,y,z) and tilt motion
• 10 mm offset from room temperature outer dewar surface

EchofMCG ™

• Gradiometer with long baseline for extra detection depth
• Special technique to isolate SQUID from Ultrasound
• Reference channels to reduce ambient noise
• Small gap to allow closer distance from sensor to source

EchofMCG ™ Features

Uses proprietary technology to bring the sensor coils very close to the subject to increase the signal/noise performance. Tristan is unique in its capacity to build thin “windows” between (cryogenic) sensor and (room temperature) source.

The small gap technology has been used to measure cortical sources in experimental animals such as rat, rabbit, pig, turtle, or monkey.

Simultaneous MCG and Echo/Doppler Recording

Simultaneous MCG and Echo/Doppler recording. Note the subtle change in E-A interval in the Doppler recording (top) in association with a change in P wave axis (middle MCG)

EchofMCG™ System Components

Sensor Unit and Dewar

•  Optional: Coils-in-vacuum design

Gantry

• Optional: Four degrees of freedom (X, Z,)

SQUID Electronics

Data Acquisition Hardware

Data Acquisition and Analysis Software

EchofMCG™ System Advantages

• Vector field mapping capability.
• Ability for deep source detection
• Synchronized fMCG and fetal ultrasound measurement.
• Advanced data processing based on spatial filtering and ICA.

About Tristan Technologies

Tristan Technologies, Inc. is a commercial supplier of SQUID-based biomagnetic and laboratory instrumentation. Tristan Technologies designs and manufactures a wide range of SQUID-based laboratory, biomagnetic, geophysical and non-destructive evaluation (NDE) instrumentation. Tristan specializes in the rapid prototyping of complex sensing devices and data processing systems. Nearly half of Tristan’s staff have advanced technical degrees, with a century’s accumulated experience in cryogenics and superconducting technology. Tristan presently occupies an 8,300 square feet facility in the Sorrento Mesa area of San Diego. This location, near UCSD, provides easy access to unique manufacturing techniques and engineering expertise.

Tristan has made SQUID based Biomedical systems to measure:

• Animal MEG
• Fetal Heart Rhythm
• Spinal cord (12 and 71-channel systems, high speed)
• Liver Iron Concentration
• Intestinal Ischemia
• Single muscle fiber
• Monitor metal/magnetic particle mobility or dispersion